AKT1 and type 2 diabetes mellitus: Consistent with this, the results of our previous study demonstrated a decreased expression level of phosphorylated Akt and ERK in PA-induced HT-22 cells, and an imbalanced expression of PI3K/Akt and ERK pathways was also presented in the hippocampus of T2DM mice through DESeq screening (X. Gao et al., 2023a).