Moreover, the neuroinflammation-related imbalance of TREM1/2 expression was also found in the hippocampus of AD and T2DM mice model, with a closely related to the glyeolipid metabolism disorder and cognitive impairment (Fan et al., 2022; X. Gao et al., 2023b). This evidence concerns the gene TREM1 and Cognitive impairment.