ALOX12 and obesity due to melanocortin 4 receptor deficiency: We found a negative correlation of TFRC with M-value and THBS1 with visceral fat, in line with previous studies.64, 65, 66 Moreover, the negative correlation between ALOX12 and TG suggests a potential role for ALOX12 in regulating lipid accumulation and distribution in T2D and obesity.67