CPNE1 and type 2 diabetes mellitus: Importantly, the expression of 116 other SEV-derived proteins differed between the insulin-resistant (IR-NDM and T2D) and the insulin-sensitive group after detraining (Supplementary Table S2) and upregulated proteins were associated with the GO-MF term “calcium-dependent phospholipid binding”, which comprises among others Copine 1 (CPNE1) (Fig. 6c and Supplementary Table S3).