On the other hand, overexpression of proteins with peroxidase activity (PRDX2, GPX3, and PTGS1) in SEV from IR-NDM compared to the other groups (T2D and IS-NDM) suggests sustained protection from oxidative damage transported via SEV, which is in line with observations immediately after HIIT in this group.24 Here, PRDX2 is linked to type 2 diabetes mellitus.