Further analysis of various subtypes of CH based on the involved genes, such as DNMT3A, TET2, ASXL1, TP53, SRSF2, JAK2, and SF3B1, revealed that DNMT3A is the most common gene associated with CH and has the greatest number of associated risk alleles (n = 23); see Table 1 (Kessler et al., 2022). The gene discussed is ASXL1; the disease is cyclic hematopoiesis.