Studies report that more than 75% of cases of CH are associated with DNMT3A, TET2, and ASXL1 variants, and 15% are associated with the next five most frequent genes: PPM1D, JAK2, SF3B1, SRSF2, and TP53 (Bick et al., 2020). This evidence concerns the gene DNMT3A and cyclic hematopoiesis.