In mice, Tet2 loss-of-function results in upregulation of inflammatory cytokines including IL-6, TNF-α, and IL-1β due to impaired intestinal barriers, and Tet2−/− mice display increased rates of atherosclerosis and colitis compared to wildtype (WT) animals (Kusne et al., 2022). Here, TET2 is linked to atherosclerosis.