FLT3 and acute myeloid leukemia: Variants involving spliceosome genes (e.g., SRSF2, SF3B1, and ZRSR2) and AML-associated genes (e.g., IDH1, IDH2, FLT3, and RUNX1) were associated with increased risk of transformation compared with other CHIP/CCUS variants, carrying a 9.26- and 13.8-fold increased risk, respectively (Weeks et al., 2022).