Again, this may be because germline variants in HRR genes associated with hereditary endometrial and ovarian cancer, such as CHEK2 and ATM, are associated with increased rates of somatic variants in DDR genes such as TP53 and PPM1D (Baranwal et al., 2022; Franco and Godley, 2024). This evidence concerns the gene PPM1D and ovarian carcinoma.