FLT3 and cyclic hematopoiesis: Bolton et al. studied 35 cases of t-MN transformation from pre-existing CH and found that 91% of cases were associated with the acquisition of additional somatic variants associated with myeloid neoplasms, including chromosomal aneuploidy and variants in genes such as FLT3, KRAS, and NRAS (Bolton et al., 2020).