DNMT3A and cyclic hematopoiesis: The genes most commonly associated with CH can be categorized as epigenetic regulators (e.g., DNMT3A, TET2, and ASXL1), DDR genes (e.g., PPM1D, TP53, CHEK2, and ATM), cellular growth signals (JAK2), and spliceosome genes (SF3B1 and SRSF2) (Joo et al., 2023).