Further analysis of various subtypes of CH based on the involved genes, such as DNMT3A, TET2, ASXL1, TP53, SRSF2, JAK2, and SF3B1, revealed that DNMT3A is the most common gene associated with CH and has the greatest number of associated risk alleles (n = 23); see Table 1 (Kessler et al., 2022). This evidence concerns the gene JAK2 and cyclic hematopoiesis.