Furthermore, the exacerbated stress response in the DMD models can be suppressed by inhibiting TRPC6 activity by pharmacological inhibitors or by guanosine 3′,5′-cyclic monophosphate–activated protein kinase G (cGMP-PKG) phosphorylation of TRPC6 (52). The gene discussed is TRPC6; the disease is Duchenne muscular dystrophy.