Women with transfusion-dependent SCD have significantly lower levels of FSH, LH,estrogen (Skillern & Rajkovic, 2008), andAMH (Chang et al., 2011).Similarly, those undergoing HSCT had undetectable AMH and FSH levels correspondingto menopause, suggesting profound ovarian insufficiency. This evidence concerns the gene BRD2 and Schnyder corneal dystrophy.