Sickle cell disease (SCD) is a generic term that defines a group of hereditarydiseases including sickle cell anemia (SCA), hemoglobin C (HbC), hemoglobin D (HbD),and beta-thalassemia, generating combinations symptomatic, called: SChemoglobinopathy (HbSC), SD hemoglobinopathy (HbSD) and S/beta-thalassemia(HbS-β-thal), characterized by a mutation in the gene encoding the hemoglobinβ subunit, resulting in the formation of abnormal sickle-shaped red bloodcells (Benenson & Porter, 2018; Kato et al., 2018). This evidence concerns the gene KRT88P and Beta-thalassemia.