To examine the effect of Casp8 deletion on tumor formation we treated WT and Casp8−/− mice with the synthetic carcinogen 4-nitroquinoline-1-oxide (4NQO), which captures the heterogeneity and many of the hallmarks of human OSCC, mimicking the carcinogenic effects of tobacco and alcohol ingestion (32). The gene discussed is CASP8; the disease is neoplasm.