Membrane‐bound IL15c is a native form of IL15 that binds with IL15Rβ/γc with higher affinity than its soluble forms.[25] In addition, the multivalent presentation of membrane‐bound IL15c on the nanovesicles is crucial for inducing optimal immune responses.[27] Second, Dox‐Fn is used for cancer cell‐specific delivery of Dox. Here, IL2RB is linked to cancer.