In an orthotopic 4T1 tumor model, the tumor growth was greatly retarded by DoxFILN (75% growth inhibition), while DoxFILN−M70 and Dox‐Fn + I‐pBMDCN with the same regimen showed 48% and 42% growth inhibition 14 days after the first injection. This evidence concerns the gene FN1 and neoplasm.