Thus, the third key feature of our design is that Dox‐Fn is transported within pH‐responsible and IL15c‐presenting nanovesicles, which have shown tumor‐targeting capability.[16, 28] The Dox‐Fn is designed to be released in the tumor microenvironment with the help of pH‐M70 to facilitate its tumor penetration and TfR1‐mediated endocytosis by cancer cells. The gene discussed is TFRC; the disease is cancer.