Factors independently associated with heightened the risk of recurrence stroke comprised age (hazard ratio [HR], 1.025; p = 0.021), diabetes mellitus (HR, 1.751; p = 0.007), Lp‐PLA2 (HR, 1.004; p < 0.001), and Lp(a) (HR, 1.002; p < 0.001). The gene discussed is LPA; the disease is diabetes mellitus.