In our investigation, we confirmed that age (HR, 1.031; 95% CI, 1.010–1.053; p = 0.031), diabetes mellitus (HR, 1.790; 95% CI, 1.189–2.694; p = 0.005), Lp‐PLA2 ≥ 134 (median) (HR, 1.824; 95% CI, 1.067–3.121; p = 0.028), and Lp(a) ≥ 260 (median) (HR, 2.294; 95% CI, 1.932–3.646; p = 0.041) were independently associated with an increased risk of stroke recurrence in AIS patients. This evidence concerns the gene PLA2G7 and diabetes mellitus.