Importantly, PRDM16 is most highly expressed in the aorta and artery, and single-cell RNA-Seq (scRNA-Seq) analysis in aortas from both humans and mice revealed that PRDM16 is predominantly expressed in VSMCs (20), where it protects against abdominal aortic aneurysm (21). The gene discussed is PRDM16; the disease is abdominal aortic aneurysm.