Remarkably, by analyzing biopsies from psoriatic skin plaques of patients with psoriasis, researchers found that a disturbed keratinization process in the parakeratotic region of psoriatic skin is associated with a very low level of caspase-14 in the cytoplasm and absence in the nucleus, suggesting that the deregulation of caspase-14 synthesis is related to disturbance of the normal, terminal keratinocyte differentiation program in patients with psoriasis [68, 136]. Here, CASP14 is linked to psoriasis.