IL18 and infection: Inflammatory caspases (caspase-1, caspase-4, and caspase-5 in humans, and caspase-11 in mice) play key roles in the innate immune response against pathogen infection and regulate the production of the pro-inflammatory cytokines: interleukin 1 beta (IL-1β) and IL-18, leading to pyroptosis [8, 26].