In vitro models of ACE2-transfected tumor cells and bioinformatics analyses of public datasets suggest that there is a link between ACE2 and PD-L1 overexpression and inhibitors of the PD1/PD-L1 axis in humans infected with SARS-CoV-2 might balance host restriction, tissue tolerance, viral enhancement mechanisms as well as improve immune cell infiltration into tumors. This evidence concerns the gene CD274 and neoplasm.