Hence, the present study aimed to assess the clinico-radiographic parameters as well as salivary levels of RANKL, OPG, IL-6, and TNF-α around standard implants- and SDI-supported fixed partial dentures in partially dentate type-2 diabetes mellitus (T2DM) patients treated for periodontitis. Here, TNFRSF11B is linked to type 2 diabetes mellitus.