Previous investigations have revealed the oncogenic mechanisms of LINC01419 within the context of HCC, such as binding to RNF169 to promote the initiation of DNA homologous recombination repair,41 increasing ZIC1 promoter methylation to inhibit ZIC1 expression and activate the PI3K/Akt signalling pathway,42 and activating the NDRG1 promoter to induce cell proliferation and metastasis.39 This evidence concerns the gene ZIC1 and hepatocellular carcinoma.