GSTM1 and atherosclerosis: We hypothesized that subjects with lower Hb levels would be protected from cardiac dysfunction, similarly to mice that have chronically active HIF response due to deficiency in the key HIF-P4H isoenzyme, HIF-P4H-2 or wild-type mice treated with a small molecule HIF-P4H inhibitor that are protected against atherosclerosis and age-induced cardiac hypertrophy [30,31].