UBE3A and Cognitive impairment: In addition, α‐thalassemia X‐linked mental retardation mutant mice show cognitive impairment with markedly increased CaMKIIα autophosphorylation (Thr‐286) levels in the PFC and Ube3a maternal‐deficient mice also show similar result in impaired memory learning and LTP with markedly increased CaMKIIα autophosphorylation (Thr‐305) levels in the hippocampus [45, 46, 47, 48].