In models of AD, AME could activate nuclear factor erythroid 2-related factor-2 (Nrf2) through affecting the adenosine monophosphate-activated protein kinase (AMPK)/GSK-3-β signaling pathway to exert antioxidant stress effects, ameliorating Aβ-induced neural function deficits and neuronal apoptosis (Chen et al., 2018). This evidence concerns the gene GSK3B and Alzheimer disease.