The top five pathways and biological processes were FCGR3A-mediated IL10 synthesis, signaling by the B-cell receptor BCR, Fcgamma receptor (Fcgr)-dependent phagocytosis, Fceri-mediated Nf-kB activation, and parasite infection as shown in Supplementary Figure 1, which were highly related to immune response. The gene discussed is FCGR2A; the disease is parasitic infectious disease.