On the contrary, in the later stages of sepsis, excessive increase of M2-type macrophages will secrete more anti-inflammatory factors IL-10, transforming growth factor-β (TGF-β), etc., contributing to immune suppression in the host (Feng et al., 2014; Murray and Wynn, 2011; Xu et al., 2019). The gene discussed is IL10; the disease is Sepsis.