Further studies have shown that MDG-1 can increase the abundance of intestinal probiotics, such as Alistipes, Ruminiclostridium, and Rikenella, which are degraded into SCFAs by intestinal flora, regulate the level of AMPK signal pathway and lipid synthesis gene in liver, thus improve the lipid metabolism of HFD mice and reduce the process of NAFLD (45). The gene discussed is DNAJB9; the disease is metabolic dysfunction-associated steatotic liver disease.