AKT1 and Insulin resistance: In the insulin resistance (IR)-induced HepG2 cell model, OJP up-regulated the mRNA and protein expressions of phosphoinositide 3-kinase (PI3K), protein kinase B (Akt), insulin receptor (InsR) and peroxisome proliferators-activated receptors γ (PPARγ) in IR HepG2 cells and decreased the mRNA and protein levels of protein tyrosine phosphatase 1B (PTP1B).