Mutation in the SNCA gene encoding the α-synuclein (αSYN) protein, is one of the mechanisms that leads to PD, with αSYN expression levels abnormally elevated in the neurons of PD patients (Sun et al., 2019; Calo et al., 2016; Polymeropoulos et al., 1997). The gene discussed is SNCA; the disease is Parkinson disease.