UBE2A and Alzheimer disease: The inhibition of the ciR-7 “sponge effect,” elevated miRNA-7 downregulates AD-associated targets such as the ubiquitin ligase UBE2A and an autophagy-related phagocytosis protein, which is required for the clearance of amyloid peptides in the AD-affected brain (Bingol and Sheng, 2011; Lonskaya et al., 2013).