CiRS-7 expression was decreased in the hippocampal tissues of AD patients, which led to abnormal Aβ aggregation through miR-7 (Zhao et al., 2016) and the nuclear transcription factor-κB (NF-κB) signaling pathway (Shi et al., 2017), respectively, while overexpression of CiRS-7 reduced Aβ aggregation. This evidence concerns the gene LINC00632 and Alzheimer disease.