Shang et al. discovered that hsa_circ_0001449 was up-regulated within ischemic stroke areas and circ_0001449 competed alongside Osbpl5 mRNA for binding to miR-124-3p and miR-32-5p to enhance ORP5 protein levels (Shang et al., 2020). This evidence concerns the gene OSBPL5 and ischemic stroke.