Shanmuganathan et al. reported relatively frequent aberrant splicing at low levels in classical CML patients with e13a2/e14a2 transcripts, with splice sites in ABL1 intron 1 dispersed over a wide region (chr9:130716382 to chr9:130854066, hg38), covering nearly the entire ABL1 intron 1 [17]. Here, LGR5 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.