With this study, we wanted to test whether levels of EVs, EV-associated and functionally active TF, and TF antigen or its counterpart TFPI correlate with E-selectin in a prospective cohort of sepsis patients with or without overt DIC in order to investigate whether a connection between endothelial activation and the manifestation of DIC can be substantiated. This evidence concerns the gene TFPI and Sepsis.