These phytoconstituents impart antioxidant and anti-inflammatory activities to the extract, making them beneficial for diversified ailments and possibly depression [9]. The current study was undertaken to evaluate the antidepressant effect of these drugs (zileuton and aqueous extract of Phyllanthus emblica) in unpredictable chronic mild stress (UCMS)-induced depression in albino mice using fluoxetine as a positive control and to assess the effect of both drugs on the hippocampal interleukin-6 (IL-6) levels (a marker of neuroinflammation) [10,11]. This evidence concerns the gene IL6 and depressive symptom measurement.