Essential adjuvants to diagnosis are HIV, EBV, HHV-8 serological studies, serum and urine electrophoresis, and molecular and genetic testing often reveals MYC amplifications and has demonstrated that plasmablastic lymphoma is genetically more closely related to diffuse large B-cell lymphoma (DLBCL) than myeloma [3,8-10]. This evidence concerns the gene MYC and diffuse large B-cell lymphoma.