An example is the rare variant rs529561493 (MAF = 0.0004) at 1q32.1 in RASSF5 that was associated (OR = 3.66) with SLE in SLE patients with steroid-associated osteonecrosis of the femoral head compared with healthy controls but not reported in other studies that included patients with more broad SLE spectrum (32). The gene discussed is RASSF5; the disease is osteonecrosis.