BAK1 and Autoimmunity: Other gene sets involving regulation of apoptosis, cell cycle, and cell homeostasis are also highly statistically relevant, including regulation of an immune checkpoint that guards against autoimmunity via apoptosis-like PD-1 signaling; Bcl-2, BAX, BAK family pathways, and regulation of B- and T-cell apoptotic processing; regulation of apoptotic cell clearance; cellular senescence and autophagy; α-synuclein signaling; cyclin D-associated events; mitotic G2/M transition checkpoint; oxidative damage; and DNA damage response.