Among other pathways, SLE-associated genes are involved in metabolic processes, protein modifications, and gene expression regulation (fatty acid synthesis, lipid and lipoprotein metabolism, protein phosphorylation and dephosphorylation, ubiquitination, regulation of nuclease activity, nucleic acid metabolism, vitamin D receptor pathway, histone acetylation, regulation of transcription, phosphatidylglycerol biosynthesis, regulation of glucose transmembrane transport, protein transport, nicotinamide nucleotide biosynthetic process). This evidence concerns the gene VDR and systemic lupus erythematosus.