These multilayer processes in SLE pathogenesis involve genes participating in apoptosis (TNFRSF21, IKBKG, IKBKB, BCL2L11, BAK1, TRAF3, IRF1, IRF3, IRF4, IRF5, IRF7, CCND2, PYCARD), regulation of ribonuclease activity (OAS1, OAS2, OAS3, OASL), complement activation (C1QB, C2, C3, C4B, CFB, ITGAM, ITGAX), and Fcγ receptor-mediated phagocytosis (FCGR2A, FCGR3A, FCGR3B, PTPRC, LYN, NCF1). This evidence concerns the gene LYN and systemic lupus erythematosus.