Nucleic acid sensing, including all three main sensing pathways, namely, cGAS-STING, RLR-MAVS, and TLRs, that activate IFN production and regulation of type I IFN production by antigen-presenting cells including dendritic cells would appear to involve many of the SLE loci, including TLR7, IRF3, IRF4, IRF5, IRF7, IRF8, STAT4, IFIH1, ITGAM, ITGAX, TRAF3, TNFAIP3, IL10, UBE2L3, IKBKB, IKBKG, IKBKE, IRAK1, IRAK4, IL12A, IL12B, PTPN11, PTPN22, USP18, RELA, JAK2, MAPKAPK2, STAT1, ATG5, and TYK2 (Supplementary Material Table S7). The gene discussed is IRF5; the disease is systemic lupus erythematosus.