NCF1 and systemic lupus erythematosus: The SLE risk allele at rs201802880 (NCF1 p.R90H), associated with reduced expression of NCF1, a negative regulator of TLR signaling, leads to decreased ROS and neutrophil extracellular trap (NET) formation, increased IFN-I detected in peripheral blood, the presence of antiphospholipid autoantibodies, and increased potentially autoreactive double-negative B cells (ABCs) (163, 164).