There are multiple examples of potential gene regulation for hundreds of genes by SLE variants (Supplementary Material Table S1), including the regulation of expression of proteins [STAT4, BLK, TNFAIP3, ITGAM, IRF5, TNFSF4, TNIP1 (aka, ABIN1), WDFY4, UBE2L3, BANK1, ETS1, and others] and regulatory RNAs [miR146a, lncRNAs DGUOK-AS1, LINC02694 (C15orf53), and others]. This evidence concerns the gene IRF5 and systemic lupus erythematosus.