The SLE risk association at 8p23.1 near the BLK gene, which encodes non-receptor tyrosine-kinase of the src family involved in B-lymphocyte development, differentiation, and signaling, is another fascinating and complex association involving multiple variants that appear to focus their effects on the promoters of BLK and FAM167. The gene discussed is NTRK1; the disease is systemic lupus erythematosus.