The possible environmental interaction is that approximately half of the SLE risk loci are bound by EBV-encoded transcription cofactors EBNA2, EBNA3C, and EBNA-LP together with human TFs such as POLAR2A, RELA, RELB, NFKB1, NFKB2, EP300, and others, forming super-enhancers (26, 97). This evidence concerns the gene NFKB1 and systemic lupus erythematosus.