Pathway analysis identified 949 drugs and compounds that may affect the expression of SLE-associated genes (Supplementary Material Table S7), including some now being used for SLE treatment (147): chloroquine, glucocorticoids, cyclophosphamide, methotrexate, cyclosporin A, prednisolone, sirolimus (rapamycin), bortezomib, baricitinib, N-acetyl-L-cysteine, atorvastatin, and vitamin D. Another identified group may cause drug-induced lupus erythematosus (148): IFN-α, IFN-β, minocycline, and sulfasalazine. Here, IFNB1 is linked to systemic lupus erythematosus.