Among the 330 SLE risk loci, 26 (8%) have leading variants that change the amino acid sequence of protein products in ways that make such a change a strong candidate for genetic causality, including AHNAK2, C1QTNF12, CD226, FCGR2A, HLA-DQB1, IFIH1, IKBKB, IRAK1, IRF3, IRF7, ITGAM, LRRK1, NCF2, NOTCH4, OAS1, PLAT, PLD2, PTPN22, TAOK3, TCP11, TSBP1, TYK2, and WDFY4 (Supplementary Material Table S1). The gene discussed is PTPN22; the disease is systemic lupus erythematosus.