The following group of expressed protein is potentially regulated by 6–11 independent SLE risk loci: GTF2I, HLA-DQA1, HLA-DRA, HLA-DRB5, GTF2IRD1, HLA-DQB1, NCF1, HLA-C, HLA-DRB1, HLA-DQA2, FDFT1, IRF8, MICA, MICB, NCF2, RASGRP1, and TYK2. The gene discussed is GTF2IRD1; the disease is systemic lupus erythematosus.