The most closely associated top 10 human transcription factors with the 53 EU ancestry lupus risk loci included in the study are RELA, NFATC1, PML, BCL3, NFIC, NFKB2, RELB, TBP, STAT5A, and TBLIXR1, with RRs from 5.54 to 25.22 (10−26 > Pc > 10−53, where Pc is the Bonferroni-corrected probability) (97). This evidence concerns the gene RELB and systemic lupus erythematosus.