In the Concord Health and Ageing in Men Project, each 1 g/dL decrement in the Hb level was associated with increased risk of major adverse CVD events (HR = 1.13), all-cause mortality (HR = 1.20), cardiovascular mortality (HR = 1.07), myocardial infarction (HR = 1.17), and heart failure (HR = 1.17) (13). The gene discussed is GSTM1; the disease is heart failure.