An instant suppression in HIV-1 LTR activation by ectopic YY1 expression and detection of a higher expression level of endogenous YY1 in HIV-1 latent cells, ACH-2, prior to reactivation support the notion that YY1 may be involved in the establishment or maintenance of HIV latency following the infection (Krishnan and Zeichner, 2004; Bernhard et al., 2013). Here, YY1 is linked to infection.