Anemia is a common comorbidity in patients with HF with an estimated approximately 30%–50% of patients with HF meeting World Health Organization (WHO) anemia thresholds [i.e., hemoglobin (Hb) <13.0 g/dl in men and <12.0 g/dl in women], which is associated with reduced ventricular free wall deformation and contractile reserve, and poor prognosis in patients with HF (12, 13). The gene discussed is GSTM1; the disease is anemia.