In Models 2 and 3, we adjusted for different confounding factors (Model II adjusted for race, gender, and age; Model 3 adjusted for gender, age, race, pH, paO2, total CO2, total bilirubin, potassium, partial thromboplastin time, prothrombin time, ALT, AST, WBC, heart rate, respiratory rate, SOFA score, GCS score, Charlson comorbidity index, myocardial infarction, paraplegia, rheumatic disease, and CRRT factors), and this association between the LAR value and 28-day mortality remained the same (see Supplementary Table S2). The gene discussed is F2; the disease is myocardial infarction.