Besides, results of single factor analysis on the difference analysis of various factors (gender, age, race, pH, paO2, total CO2, total bilirubin, potassium, partial thromboplastin time, prothrombin time, ALT, AST, WBC, heart rate, respiratory rate, SOFA score, GCS score, Charlson comorbidity index, myocardial infarction, paraplegia, rheumatic disease, and CRRT factors) between the death group and the non-death group were shown in Supplementary Table S3. Here, F2 is linked to rheumatic disorder.