In colon cancer, MSCs enhance stemness and epithelial–mesenchymal transition through interleukin-8 (IL-8)/CXC chemokine receptor 2 (CXCR2)/mitogen-activated protein kinase (MAPK) and fibroblast growth factor 10 (FGF10)–protein kinase A (PKA)–protein kinase B (Akt)–β-catenin signaling pathways [5]. Here, AKT1 is linked to malignant colon neoplasm.