Importantly, silymarin’s influence on neurotrophic factors, as evidenced by increased BDNF levels, aligns with existing literature highlighting its anti-inflammatory and antioxidant effects in several neurological-related models, including cerebral ischemia, translating into improved motor function and BDNF content recovery in animals (Song et al., 2016; Thakare et al., 2017; Yon et al., 2019; Moghaddam et al., 2020; Shokouhi et al., 2020; Ramirez-Carreto et al., 2023). The gene discussed is BDNF; the disease is Cerebral ischemia.