Additionally, cortical CX3CL1, fractalkine, a key microglial regulatory chemokine, was significantly increased in the HFD + I + S mice (p = 0.0091 compared to ND + I, p = 0.0022 compared to HFD + I, p = 0.0068 compared to ND + I + S; Figure 5E), suggesting its role in reducing excitotoxic damage and improving stroke outcomes. This evidence concerns the gene CX3CL1 and stroke disorder.