While our study identified optimal cut-off at 62.4 ng/ml, different studies suggested different cut-off points for IGF-1, which may reflect the effect of various etiologies of primary liver disease and cirrhosis on IGF-1 levels and may necessitate further validation or individualisation of the optimal cut-off [20], [23], [24], [35]. This evidence concerns the gene IGF1 and Cirrhosis.