CDKN2A and urinary bladder cancer: As depicted in Fig. 1A, approximately nine out of nineteen cuproptosis-related genes, including NFE2L2, NLRP3, ATP7A, SLC31A1, LIPT2, MTF1, CDKN2A, GCSH and DLST, displayed significant differences between normal and bladder cancer tissues in the TCGA database.