Moreover, the secretion of IFN-γ by both NK cells and T cells not only amplifies the expression of PD-L1 on tumor cells, but also triggers the JAK1, JAK2, and STAT1 pathways, ultimately bolstering the tumor's ability to evade immune surveillance (Padmanabhan et al., 2022[73]). The gene discussed is CD274; the disease is neoplasm.