CTLA4 and celiac disease: In the clinical picture of patients with CTLA-4 insufficiency, we can observe symptoms related to the hematopoietic system (pancytopenia and hypogammaglobulinemia, lymphoproliferation), respiratory infections, autoimmune endocrinopathies, and also to the digestive system (autoimmune hepatitis, primary sclerosing cholangitis, autoinflammatory intestinal diseases, celiac disease), dermatological diseases (psoriasis, atopic dermatitis) and rheumatic diseases (6–8).