Moreover, EVs derived from interferon-β (IFN-β)-primed MSCs down-regulated the expression of RA-associated cytokines (IL-4, GM-CSF, IFN-γ, IL-2, TNF-α) and diminished CD4+ T-cell polyfunctionality in RA CD4+ T cells (82). The gene discussed is IFNG; the disease is rheumatoid arthritis.