NFKB1 and Familial prostate cancer: A further structural-based virtual screening study established that exposure of prostate cancer cells to a natural product-like inhibitor inhibited the interaction between Pin1 and the NF-κB p65 subunit, thereby resulting in a reduction of nuclear p65 (Thr 254) phosphorylation, thereby attenuating NF-κB activity and promoting apoptosis (84).