Furthermore, c-Jun N-terminal kinase (JNK) has been found to phosphorylate Pin1 at residue Ser115, thereby inhibiting monoubiquitination at Lys117, which prevents proteasomal degradation and facilitates the progression of intrahepatic cholangiocarcinoma (ICC) (61). Here, MAPK8 is linked to intrahepatic cholangiocarcinoma.