PIN1 and hepatocellular carcinoma: Furthermore, the seed region of miR-296-5p has been demonstrated to interact directly with the 3′-UTR of Pin1 mRNA, thereby influencing the proliferation and anchorage-independent growth of prostate cancer cells (49), whereas by modulating Pin1 expression, miR-140-5p and miR-874-3p have been found to inhibit cell growth and colony formation and promote apoptosis in HCC (50, 51).