We compared the CRISP3 plasma concentrations between sepsis and non-sepsis patients, and the results revealed that CRISP3 concentrations were greatly elevated in sepsis patients (1.305 ± 0.535 ng/mL vs. 0.743 ± 0.270 ng/mL, p < 0.001; Figure 2A), which were in line with the results of the meta-analysis. Here, CRISP3 is linked to Sepsis.