G6PD and neoplasm: Moreover, HPD, closely linked to G6PD transcription, enhances tyrosine breakdown metabolism, elevating acetyl CoA levels for histone acetylation, and promoting HDAC10 translocation to the cytoplasm through LKB1/AMPK signaling, thereby controlling histone acetylation and boosting G6PD transcription, PPP flux, and tumor progression[42].