To test this hypothesis, we first analyzed the correlation between Fra-1 expression and ferroptosis-related molecules GPX4, SLC7A11, and FTH1 in GC cells through the GEPIA2 website using STAD correlation data in TCGA, and the results showed that Fra-1 was significantly and positively correlated with GPX4, SLC7A11, and FTH1. This evidence concerns the gene GPX4 and gastric cancer.