These include the insulin-like growth factor (IGF) system, the Ras/ERK/mitogen-activated protein kinase (MAPK) pathway, the PI3K/AKT pathway, and the TGF-beta signaling pathway, which are frequently deregulated in cancer cells and associated with resistance to therapy[8,9], suggesting that lipid metabolism and signaling pathways are closely linked. This evidence concerns the gene AKT1 and cancer.