FASN and cancer: In addition, KRAS mutations have been shown to increase FASN expression in LUAC, which in turn promoted the synthesis of monounsaturated fatty acids (MUFAs) and saturated fatty acids (SFAs) [Figure 5], thereby preventing ferroptosis in cancer cells[38], a form of cell death induced by the peroxidation of polyunsaturated membrane phospholipids[39].