CD8A and neoplasm: However, in clear cell renal cell carcinoma (ccRCC), high expression of ST3GAL5 correlated with a dysfunctional state of CD8+ cells and predicted poor clinical outcome[24], and in avian neural crest cells, sphingolipids metabolism promoted the activation of the Wnt and bone morphogenetic protein (BMP) pathways, which are critical for the development of the EMT process, suggesting that the role of sphingolipids may differ depending on the tumor type[25].