Periostin (POSTN) produced by cancer cells induced secretion of the chemokine CC motif chemokine ligand 2 (CCL2) by endothelial progenitor cells (EPCs) [Figure 8], which in turn promoted a metastatic phenotype in HCC cells by increasing CD36 expression through the CCR2/STAT3 signaling pathway[86] [Table 4]. Here, POSTN is linked to cancer.