For instance, the E3 ubiquitin ligase tripartite motif-containing 21 (TRIM21) acts as a suppressor of ferroptosis by promoting K63 ubiquitination and plasma membrane translocation of FSP1, making it a potential therapeutic target to enhance chemosensitivity in ferroptosis-resistant hepatocellular carcinoma and pancreatic cancer[110]. The gene discussed is AIFM2; the disease is familial pancreatic carcinoma.