Extracellular vesicles (EVs) derived from adipose tissue‐derived stem cells in creeping fat (CrF) improve lymphatic functions and increase mesenteric lymphatic vessel density of Il‐10‐/– mice, leading to decreased colitis and mesenteritis through the miR‐132‐3p/RASA1 /ERK1/2 axis. Here, IL10 is linked to colitis.