Coculturing M1‐exos or si‐IRF5 M1‐exos with lung cancer cells from both Vector and OE‐HLA‐E groups demonstrated that overexpression of HLA‐E led to decreased metabolic activity and viability of A549 and SPC‐A1 cells, irrespective of coculture conditions (Figure 5C). This evidence concerns the gene HLA-E and lung cancer.