The GEPIA database showed that HLA‐E expression levels in lung cancer tissues were significantly downregulated (347 normal‐tissue samples and 483 tumor samples) (Figure 4A), and the GEO dataset (49 normal‐tissue samples and 58 tumor samples, p < 0.0001) (Figure 4B) and TCGA datasets (59 normal‐tissue samples and 515 tumor samples, p < 0.0001) (Figure 4C) also showed similar results, with significantly reduced HLA‐E mRNA levels in lung cancer tissues. The gene discussed is HLA-E; the disease is neoplasm.