In our previous study [22], we found that the absence of Ghr in fat exacerbated diet-induced obesity in male KO mice, and the maternal genotype did not affect this outcome in male offspring (Figure S2B and S2C) (Figure S2B: n = 6–8, two-way ANOVA; F (3, 125) = 12.43, p < 0.0001) (Post hoc comparison, Tukey’s multiple comparisons test, *p < 0.05 from week 20) (Figure S2C: One-way ANOVA; F (3, 24) = 9.377, p = 0.0003) (post hoc comparison, Tukey’s multiple comparisons test, *p < 0.05 and **p < 0.01). Here, GHR is linked to obesity due to melanocortin 4 receptor deficiency.