Consistent with these findings, the GTT and ITT showed that feeding from a KO mother significantly increased the insulin sensitivity of L-LL and L-KO offspring when challenged with a HF diet (Fig. 7F and J) (Fig. 7J: n = 4–6, one-way ANOVA; F (7, 33) = 3.369, p = 0.008) (post hoc comparison, Tukey’s multiple comparisons test, *p < 0.05), but glucose tolerance was not affected (Fig. 7G and K). The gene discussed is INS; the disease is hydrops fetalis.