NR5A1 and disorder of sexual differentiation: NR5A1 variants are considered one of the most common causes of 46, XY DSD, with a frequency of 8.5% (2/23) in Egyptian patients [43], 6.5% (5/77)−9% (9/100) in European patients [36, 44] and 8.6% (6/70) in Chinese patients [10], which was reported in several studies and confirmed as 8.5% (19/223) in our study.