PPARA and type 2 diabetes mellitus: Indeed, 16 of the 19 CpG sites with lower methylation in muscle from twins with T2D and being annotated to genes which are part of the downregulated GLUT4 translocation pathway are in the gene body, while 5 of 6 CpG sites with lower methylation in muscle from twins with T2D and being annotated to genes which are part of the upregulated “regulation of lipid metabolism by peroxisome proliferator-activated receptor alpha (PPARalpha)” pathway are in promoter regions.