Of note, downregulated gene sets in myoblasts from subjects with T2D include pathways involved in, i.e., ECM organization, metabolism of lipids, vesicle-mediated transport, signaling by receptor tyrosine kinases, and axon guidance, which are pathway groups also downregulated in skeletal muscle from MZ twins with T2D (Fig. 2G). This evidence concerns the gene NTRK1 and type 2 diabetes mellitus.