Here, we found 73 genes to exhibit differential expression in both skeletal muscle from twins with T2D and in myoblasts from subjects with T2D based on nominal P < 0.05 (Additional file 1: Supplemental Table 6 and Additional file 1: Supplemental Fig. 1B), including genes encoding proteins involved in regulation of insulin sensitivity (i.e., EGR2 and FABP3) and muscle growth (FSD1 and IGFBP3). The gene discussed is INS; the disease is type 2 diabetes mellitus.