Here, we found 73 genes to exhibit differential expression in both skeletal muscle from twins with T2D and in myoblasts from subjects with T2D based on nominal P < 0.05 (Additional file 1: Supplemental Table 6 and Additional file 1: Supplemental Fig. 1B), including genes encoding proteins involved in regulation of insulin sensitivity (i.e., EGR2 and FABP3) and muscle growth (FSD1 and IGFBP3). This evidence concerns the gene IGFBP3 and type 2 diabetes mellitus.