Interestingly, genes affecting lipid metabolism and regulation of DNA methylation, including, i.e., the genes ELOVL5, ELOVL6, FASN, and MTHFD1 were downregulated in both skeletal muscle, as seen in the present study, and adipose tissue [43] from MZ twins with T2D. The gene discussed is ELOVL5; the disease is type 2 diabetes mellitus.