SETBP1 and type 2 diabetes mellitus: A CpG site in SETBP1, which encodes the SET-binding protein 1, had the largest increase in DNA methylation in muscle from twins with T2D compared with non-T2D co-twins, and this gene also showed decreased mRNA expression in skeletal muscle from subjects with T2D, both in the twin cohort and the validation cohort including unrelated subjects [12].