Among the two differentially expressed genes encoding transcription factors with enrichment of binding sites in the promoters of dysregulated genes, cg23458613 in the TSS1500 of KLF11 displayed reduced DNA methylation in twins with T2D compared with co-twins without T2D (P < 0.05, Fig. 3C). The gene discussed is KLF11; the disease is type 2 diabetes mellitus.