Specifically, CTCF can bind to the promoter region of the tumor suppressor gene P53 to inhibit the enrichment of chromatin repression markers such as H3K9me3, H3K27me3, and H4K20me3, thereby maintaining the transcriptional activity of P53 and exerting a tumor suppressor function in various tumor cells [39]. This evidence concerns the gene TP53 and neoplasm.