It can inhibit angiogenesis in rheumatoid arthritis by targeting the interleukin (IL)-6/Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3)/vascular endothelial growth factor (VEGF) signaling pathway [13] and also has the potential to treat primary biliary cholangitis [14] and multiple sclerosis [15]. This evidence concerns the gene STAT3 and rheumatoid arthritis.