To investigate the involvement of SENP3 in PCa metastasis, we first analyzed several publicly available Gene Expression Omnibus (GEO) databases [31–33] and observed that the SENP3 mRNA levels were significantly increased in metastatic PCa tissues, compared with the normal prostate or primary PCa tissues (Fig. 3A–C). The gene discussed is SENP3; the disease is posterior cortical atrophy.