SMDT1 and neurodegenerative disease: Most of these studies report that MCUa, MCUb, MICU1-2, and EMRE have important functional relevance in immunity, muscle cell physiology, as well as pathological conditions such as cancer, cardiovascular and neurodegenerative diseases, among others (Kwong et al, 2015; Marchi et al, 2019; O’Rourke et al, 2021; Patron et al, 2018; Qin et al, 2023; Seegren et al, 2020; Stejerean-Todoran et al, 2022; Tosatto et al, 2016; Vultur et al, 2018; Walters and Usachev, 2023).